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What clinical trials and scientific research supports Liquid BioCell™ Life’s claims of healthy aging, active joints and younger-looking skin?

Article ID: 69410 Print
What clinical trials and scientific research supports Liquid BioCell™ Life’s claims of healthy aging, active joints and younger-looking skin?


1) Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation. Schauss et
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2) A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II (Liquid
BioCell™) in adults with osteoarthritis. Sheldon et al. 2003, Miami Research Associates.
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chemopreventive agent. Cancer Epidemiol Biomarkers Prev. 2007, Vols. 16(6): 1246-52.
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6) Eects of Oral Administration of Type II Collagen on Rheumatoid Arthritis. Trentham et al. 1993, Science, pp. 261:
7) Suppression of Type II Collagen-Induced Arthritis by the Intravenous Administration of Type II Collagen or Its
Constituent Peptide. Englert et al. 1984, Cell Immuno, pp. 87: 357-365.
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interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Loeser et al. 2002, Arthritis
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12) Oxidants, oxidative stress and the biology of aging. Finkel et al. 2000, Nature, pp. 408: 239-247.
13) Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative
stress induces chondrocyte telomere instability and down-regulation of chondrocyte
function. Yudoh et al. 2005, Arthritis Res Ther, pp. 7: R380-R391.
14) Telomere erosion and senescence in human articular cartilage chondrocytes, Martin et al. 2001, J Gerontol A Biol
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15) Loeser. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.
Osteoarthritis and Cartilage. 2009, Vols. 17:971-979.
16) Hyaluronic acid in cutaneous intrinsic aging. Ghersetich et al. 1994, Int J Dermatol, pp. 33(2): 119-122.
17) Stern et al. Hyaluronan catabolism: a new metabolic pathway. Eur J Cell Biol. 2004, Vols. 83(7): 317-325.
18) Wiest et al. Native hyaluronic acid in dermatology-results of an expert meeting. J Dtsch Dermatol Ges. 2008, Vols.
6(3): 176-180.
19) Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase- 1 in fibroblasts in aged
human skin. Fisher et al. 2009, Am J Path, pp. 174: 101-114.
20) Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of
hyaluronic acid syntheisis. Dai et al. 2007, Am J Path, pp. 282: 1451-1561.
21) Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. Greco et al. 1998, J Cell Physiol,
pp. 177(3): 465-473.
22) Hyaluronan facilitates transforming growth factor-beta1-mediated fibroblastproliferation. Meran et al. 2008, J Biol
Chem, pp. 283: 6530-6545.
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27) Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.
Geesin et al. 1988, J Invest Dermatol, pp. 90(4): 420-424.28.
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29) Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. Chidambara et
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30) Photochemopreventive eect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in
normal human epidermal keratinocytes. Syed et al. 2006, Photochem Photobiol, pp. 82(2): 398-405.
31) Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation- induced human dermal fibroblasts. Bae
et al. 2009, Mol Nutr Food Res, pp.53(6): 726-738.
32) Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin.
Aziz et al. 2005, Phytochem Photobiol, pp. 81(1): 25-31.
33) Chemoprevention of skin cancer by grape constituent Resveratrol: relevance to human disease? Aziz et al. 2005,
FASEB J, pp. 19(9): 1193-1195.34) A multitargeted agent for age-associated chronic diseases. Kuzhuvelil et al. 2008, Cell Cycle, p. 7:8.
35) A low dose of dietary Resveratrol partially mimics caloric restriction and retards aging parameters in mice. Barger et
al. 2008, PLoS One, p. 3(6): e2264.
36) Schauss et al. 2012. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, Liquid
BioCell, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. J
Agric Food Chem. 60(16): 4096-101.
37) Schwartz et al. 2012. Ingestion of Liquid BioCell, a novel hydrolyzed chicken sternal cartilage extract, enhanced
blood microcirculation and reduced facial aging signs. Clin Interv Aging. 7: 267-273.


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