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What clinical trials and scientific research supports Liquid BioCell™ Life’s claims of healthy aging, active joints and younger-looking skin?

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What clinical trials and scientific research supports Liquid BioCell™ Life’s claims of healthy aging, active joints and younger-looking skin?

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1) Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation. Schauss et
al. 2007, Food Chem Toxicol, pp. 45:315-321.
2) A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II (Liquid
BioCell™) in adults with osteoarthritis. Sheldon et al. 2003, Miami Research Associates.
3) Boocock et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of Resveratrol, a potential
chemopreventive agent. Cancer Epidemiol Biomarkers Prev. 2007, Vols. 16(6): 1246-52.
4) Articular cartilage: structure, injuries and review of management. Bhosale et al. 2008, Brit Med Bull, pp. 87: 77-95.
5) Aggrecan, aging, and assembly in articular cartilage. Dudhia. 2005, Cell Mol Life Sci, pp. 62: 2241-2256.
6) Eects of Oral Administration of Type II Collagen on Rheumatoid Arthritis. Trentham et al. 1993, Science, pp. 261:
1727-1730.
7) Suppression of Type II Collagen-Induced Arthritis by the Intravenous Administration of Type II Collagen or Its
Constituent Peptide. Englert et al. 1984, Cell Immuno, pp. 87: 357-365.
8) Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Bello et
al. 2006, Curr Med Res Opin, pp.22(11): 2221-2232.
9) Hyaluronan synthesis and degradation in cartilage and bone. Bastow. 2008, Cell Mol Life Sci, pp. 65: 395-413.
10) Stimulation of type II collagen biosyntheisis and secretion in bovine chondrocytes cultured with degraded collagen.
Oesser et al. 2003, Cell Tissue Res, pp. 399: 393-399.
11) Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of
interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Loeser et al. 2002, Arthritis
Rheum , pp. 46: 2349-2357.
12) Oxidants, oxidative stress and the biology of aging. Finkel et al. 2000, Nature, pp. 408: 239-247.
13) Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative
stress induces chondrocyte telomere instability and down-regulation of chondrocyte
function. Yudoh et al. 2005, Arthritis Res Ther, pp. 7: R380-R391.
14) Telomere erosion and senescence in human articular cartilage chondrocytes, Martin et al. 2001, J Gerontol A Biol
Sci Med Sci, pp. 56: B172-B179.
15) Loeser. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.
Osteoarthritis and Cartilage. 2009, Vols. 17:971-979.
16) Hyaluronic acid in cutaneous intrinsic aging. Ghersetich et al. 1994, Int J Dermatol, pp. 33(2): 119-122.
17) Stern et al. Hyaluronan catabolism: a new metabolic pathway. Eur J Cell Biol. 2004, Vols. 83(7): 317-325.
18) Wiest et al. Native hyaluronic acid in dermatology-results of an expert meeting. J Dtsch Dermatol Ges. 2008, Vols.
6(3): 176-180.
19) Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase- 1 in fibroblasts in aged
human skin. Fisher et al. 2009, Am J Path, pp. 174: 101-114.
20) Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of
hyaluronic acid syntheisis. Dai et al. 2007, Am J Path, pp. 282: 1451-1561.
21) Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. Greco et al. 1998, J Cell Physiol,
pp. 177(3): 465-473.
22) Hyaluronan facilitates transforming growth factor-beta1-mediated fibroblastproliferation. Meran et al. 2008, J Biol
Chem, pp. 283: 6530-6545.
23) Aging: a theory based on free radical and radiation chemistry. Harman. 1956, J Gerontol, pp. 11(3): 298-300.
24) Enzymatic and nonenzymatic antioxidants in epidermis and dermis of human skin. Shindo et al. 1994, J Invest
Dermatol, pp. 102(1): 122-124.
25) Intake of flavonoids and flavones and risk of coronary heart disease in male smokers. Hirvonen et al. 2001, Epide
miology, pp. 12: 62-67.
26) In vivo exposure to ozone depletes vitamins C and E and induces lipid peroxidation in epidermal layers of murine
skin. Thiele et al. 1997, Free Radic Biol Med, pp. 23(3): 385-91.
27) Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast.
Geesin et al. 1988, J Invest Dermatol, pp. 90(4): 420-424.28.
28) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Gil et al.
2000, J Agric Food Chem, pp. 48(10): 4581-4589.
29) Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. Chidambara et
al. 2000, J Agric Food Chem, pp. 50(17): 4791-4795.
30) Photochemopreventive eect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in
normal human epidermal keratinocytes. Syed et al. 2006, Photochem Photobiol, pp. 82(2): 398-405.
31) Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation- induced human dermal fibroblasts. Bae
et al. 2009, Mol Nutr Food Res, pp.53(6): 726-738.
32) Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin.
Aziz et al. 2005, Phytochem Photobiol, pp. 81(1): 25-31.
33) Chemoprevention of skin cancer by grape constituent Resveratrol: relevance to human disease? Aziz et al. 2005,
FASEB J, pp. 19(9): 1193-1195.34) A multitargeted agent for age-associated chronic diseases. Kuzhuvelil et al. 2008, Cell Cycle, p. 7:8.
35) A low dose of dietary Resveratrol partially mimics caloric restriction and retards aging parameters in mice. Barger et
al. 2008, PLoS One, p. 3(6): e2264.
36) Schauss et al. 2012. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, Liquid
BioCell, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. J
Agric Food Chem. 60(16): 4096-101.
37) Schwartz et al. 2012. Ingestion of Liquid BioCell, a novel hydrolyzed chicken sternal cartilage extract, enhanced
blood microcirculation and reduced facial aging signs. Clin Interv Aging. 7: 267-273.

 


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